作者
Frank Edelmann, Götz Gelbrich, Hans-Dirk Düngen, Stefan Fröhling, Rolf Wachter, Raoul Stahrenberg, Lutz Binder, Agnieszka Töpper, Diana Jahandar Lashki, Silja Schwarz, Christoph Herrmann-Lingen, Markus Löffler, Gerd Hasenfuss, Martin Halle, Burkert Pieske
发表日期
2011/10/18
期刊
Journal of the American College of Cardiology
卷号
58
期号
17
页码范围
1780-1791
出版商
American College of Cardiology Foundation
简介
Objectives
We sought to determine whether structured exercise training (ET) improves maximal exercise capacity, left ventricular diastolic function, and quality of life (QoL) in patients with heart failure with preserved ejection fraction (HFpEF).
Background
Nearly one-half of patients with heart failure experience HFpEF, but effective therapeutic strategies are sparse.
Methods
A total of 64 patients (age 65 ± 7 years, 56% female) with HFpEF were prospectively randomized (2:1) to supervised endurance/resistance training in addition to usual care (ET, n = 44) or to usual care alone (UC) (n = 20). The primary endpoint was the change in peak Vo2 after 3 months. Secondary endpoints included effects on cardiac structure, diastolic function, and QoL.
Results
Peak Vo2 increased (16.1 ± 4.9 ml/min/kg to 18.7 ± 5.4 ml/min/kg; p < 0.001) with ET and remained unchanged (16.7 ± 4.7 ml/min/kg to 16.0 ± 6.0 ml/min/kg; p = NS) with …
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F Edelmann, G Gelbrich, HD Düngen, S Fröhling… - Journal of the American College of Cardiology, 2011