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Proper choice and design of nanocarriers is imperative to achieve the desired therapeutic benefits. Herein, we report a facile methodology for preparation of chemically cross-linked AG-G5 hybrid nanogels of alginate (AG) and G5.0 poly(amidoamine) (PAMAM) dendrimer via carbodiimide chemistry. The rationale behind the formulation of AG-G5 nanogels is to attain effective and sustained delivery of chemotherapeutic agents. Physical entrapment of anticancer drug epirubicin (EPI) within AG-G5 nanogels endows them with therapeutic properties. Analytical techniques such as zeta potential (ζ) measurements, field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FTIR) confirm the integration of PAMAM dendrimer with alginate structure. Thermal, swelling studies, and surface area estimations suggest improved stability and …