作者
Bharat Bhushan, S Uday Kumar, Ishita Matai, Abhay Sachdev, Poornima Dubey, Packirisamy Gopinath
发表日期
2014/10/1
来源
Journal of Biomedical Nanotechnology
卷号
10
期号
10
页码范围
2950-2976
出版商
American Scientific Publishers
简介
Ferritin is a ubiquitous iron storage protein responsible for maintaining the iron homeostasis in living organism and thereby protects the cell from oxidative damage. The ferritin protein cages have been used as a reaction vessel for the synthesis of various non-native metallic nanoparticles inside its core and also used as a nanocarrier for various applications. Lack of suitable non-viral carrier for targeted delivery of anticancer drugs and imaging agents is the major problem in cancer therapy and diagnosis. The pH dependent reversible assembling and disassembling property of ferritin renders it as a suitable candidate for encapsulating a variety of anticancer drugs and imaging probes. Ferritins external surface is chemically and genetically modifiable which can serve as attachment site for tumor specific targeting peptides or moieties. Recent studies, further establishes ferritin as a multifunctional nanocarrier for …
引用总数
20142015201620172018201920202021202220232024198727511646
学术搜索中的文章
B Bhushan, SU Kumar, I Matai, A Sachdev, P Dubey… - Journal of Biomedical Nanotechnology, 2014