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Objectives: To compare a proprietary extract of American ginseng, CVT‐E002, with placebo in preventing acute respiratory illness (ARI) in an institutional setting during the influenza season.

Design: Two randomized, double‐blind, placebo‐controlled trials conducted late in the 2000 (8 week) and 2000–2001 (12 week) influenza seasons.

Setting: Long‐term care setting that included nursing home and assisted living at three sites.

Participants: Eighty‐nine (2000) and 109 (2000–2001) enrolled subjects, average age 81 and 83.5, respectively; 74% women. Approximately 90% had received influenza vaccine in each of the 2 years.

Intervention: Oral twice‐daily administration of a proprietary ginseng extract, CVT‐E002, 200 mg or placebo.

Measurements: ARI was defined as two new respiratory symptoms or one with a constitutional symptom. Confirmation of viral ARI was by culture (influenza or respiratory syncytial …