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Background

Renovascular disease and cerebrovascular disease are among the top 10 causes of death in elderly people. Measures of GFR correlate with kidney disease, whereas white matter hyperdensities (WMHs) correlate with cerebrovascular disease. Little is published describing the occurrence and severity of these together. We hypothesize that both renovascular and cerebrovascular conditions share a common origin and the presence of one predicts the presence of the other, both in terms of occurrence and severity.

Methods

We conducted a randomized retrospective chart review of inpatients aged 60 to 70 years in a tertiary care teaching hospital between January 1, 2004, and May 31, 2005, who had brain imaging and serum creatinine measurement done during their hospitalization. A sample size was set for an alpha level of 0.05 to detect r>. 5 with 80% power. Subjects' medical records were reviewed for …