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Pneumonia and influenza lead as vaccine-preventable infections among nursing home (NH) residents. Immunosenescence reduces vaccine response and protection from infections. More immunogenic vaccines, e.g., adjuvanted trivalent influenza vaccine [aTIV], can improve clinical outcomes. We evaluated all-cause hospitalization among long-stay NH residents offered aTIV vs. trivalent influenza vaccine (TIV).

We randomized 823 NHs within 75 miles of a Centers for Disease Control and Prevention influenza reporting city to offer one of the two egg-based influenza vaccines, aTIV or TIV, as their 2016–2017 influenza season standard of care. For the subset of long-stay NH residents (>100 days in facility as of October 1, 2016) aged ≥65 years, we determined how many were hospitalized from November 1, 2016 to June 1, 2017 on an intent-to-treat basis …