作者
Laura C Bahlmann, Alexander EG Baker, Chang Xue, Sophie Liu, Moritz Meier‐Merziger, Danielle Karakas, Luke Zhu, Ileana Co, Spencer Zhao, Allysia Chin, Alison McGuigan, John Kuruvilla, Rob C Laister, Molly S Shoichet
发表日期
2021/7
期刊
Advanced Functional Materials
卷号
31
期号
28
页码范围
2170205
简介
In article number 2008400, Molly S. Shoichet and co-workers demonstrate macrophage invasion into an oxime-crosslinked cryogel comprised of gelatin-oxyamine and hyaluronan-aldehyde. The macrophages migrate by actively degrading the matrix and through the pores. IL4/IL13-stimulated cells (flat cells) migrate further than IFNγ/LPS-stimulated cells (spikey cells). These cryogels allow for emulating the extracellular environment of cancer—a key parameter in macrophage invasion. Image concept by Laura Bahlmann and created by Ella Maru Studio.