作者
Olivo Miotto, Jacob Almagro-Garcia, Magnus Manske, Bronwyn MacInnis, Susana Campino, Kirk A Rockett, Chanaki Amaratunga, Pharath Lim, Seila Suon, Sokunthea Sreng, Jennifer M Anderson, Socheat Duong, Chea Nguon, Char Meng Chuor, David Saunders, Youry Se, Chantap Lon, Mark M Fukuda, Lucas Amenga-Etego, Abraham VO Hodgson, Victor Asoala, Mallika Imwong, Shannon Takala-Harrison, François Nosten, Xin-zhuan Su, Pascal Ringwald, Frédéric Ariey, Christiane Dolecek, Tran Tinh Hien, Maciej F Boni, Cao Quang Thai, Alfred Amambua-Ngwa, David J Conway, Abdoulaye A Djimdé, Ogobara K Doumbo, Issaka Zongo, Jean-Bosco Ouedraogo, Daniel Alcock, Eleanor Drury, Sarah Auburn, Oliver Koch, Mandy Sanders, Christina Hubbart, Gareth Maslen, Valentin Ruano-Rubio, Dushyanth Jyothi, Alistair Miles, John O'Brien, Chris Gamble, Samuel O Oyola, Julian C Rayner, Chris I Newbold, Matthew Berriman, Chris CA Spencer, Gilean McVean, Nicholas P Day, Nicholas J White, Delia Bethell, Arjen M Dondorp, Christopher V Plowe, Rick M Fairhurst, Dominic P Kwiatkowski
发表日期
2013/6
期刊
Nature genetics
卷号
45
期号
6
页码范围
648-655
出版商
Nature Publishing Group US
简介
We describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia. Within this relatively small geographic area, we have discovered several distinct but apparently sympatric parasite subpopulations with extremely high levels of genetic differentiation. Of particular interest are three subpopulations, all associated with clinical resistance to artemisinin, which have skewed allele frequency spectra and high levels of haplotype homozygosity, indicative of founder effects and recent population expansion. We provide a catalog of SNPs that show high levels of differentiation in the artemisinin-resistant subpopulations, including codon variants in transporter proteins and DNA mismatch repair proteins. These data provide a population-level genetic framework for …
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O Miotto, J Almagro-Garcia, M Manske, B MacInnis… - Nature genetics, 2013
