作者
A Marc Gillinov, Annetine C Gelijns, Michael K Parides, Joseph J DeRose Jr, Alan J Moskowitz, Pierre Voisine, Gorav Ailawadi, Denis Bouchard, Peter K Smith, Michael J Mack, Michael A Acker, John C Mullen, Eric A Rose, Helena L Chang, John D Puskas, Jean-Philippe Couderc, Timothy J Gardner, Robin Varghese, Keith A Horvath, Steven F Bolling, Robert E Michler, Nancy L Geller, Deborah D Ascheim, Marissa A Miller, Emilia Bagiella, Ellen G Moquete, Paula Williams, Wendy C Taddei-Peters, Patrick T O'Gara, Eugene H Blackstone, Michael Argenziano
发表日期
2015/4/9
期刊
New England Journal of Medicine
卷号
372
期号
15
页码范围
1399-1409
出版商
Massachusetts Medical Society
简介
Background
Among patients undergoing mitral-valve surgery, 30 to 50% present with atrial fibrillation, which is associated with reduced survival and increased risk of stroke. Surgical ablation of atrial fibrillation has been widely adopted, but evidence regarding its safety and effectiveness is limited.
Methods
We randomly assigned 260 patients with persistent or long-standing persistent atrial fibrillation who required mitral-valve surgery to undergo either surgical ablation (ablation group) or no ablation (control group) during the mitral-valve operation. Patients in the ablation group underwent further randomization to pulmonary-vein isolation or a biatrial maze procedure. All patients underwent closure of the left atrial appendage. The primary end point was freedom from atrial fibrillation at both 6 months and 12 months (as assessed by means of 3-day Holter monitoring).
Results
More patients in the ablation group than …
学术搜索中的文章
AM Gillinov, AC Gelijns, MK Parides, JJ DeRose Jr… - New England Journal of Medicine, 2015