作者
R Kaaks, S Rinaldi, TJ Key, F Berrino, PHM Peeters, C Biessy, L Dossus, A Lukanova, S Bingham, KT Khaw, NE Allen, HB Bueno-de-Mesquita, CH Van Gils, D Grobbee, H Boeing, PH Lahmann, G Nagel, J Chang-Claude, F Clavel-Chapelon, A Fournier, A Thiébaut, CA González, JR Quirós, MJ Tormo, E Ardanaz, P Amiano, V Krogh, D Palli, Salvatore Panico, R Tumino, P Vineis, A Trichopoulou, V Kalapothaki, D Trichopoulos, P Ferrari, T Norat, R Saracci, E Riboli
发表日期
2005/12/1
期刊
Endocrine-related cancer
卷号
12
期号
4
页码范围
1071-1082
出版商
BioScientifica
简介
Considerable experimental and epidemiological evidence suggests that elevated endogenous sex steroids — notably androgens and oestrogens — promote breast tumour development. In spite of this evidence, postmenopausal androgen replacement therapy with dehydroepiandrosterone (DHEA) or testosterone has been advocated for the prevention of osteoporosis and improved sexual well-being. We have conducted a case–control study nested within the European Prospective Investigation into Cancer and Nutrition. Levels of DHEA sulphate (DHEAS), (Δ4-androstenedione), testosterone, oestrone, oestradiol and sex-hormone binding globulin (SHBG) were measured in prediagnostic serum samples of 677 postmenopausal women who subsequently developed breast cancer and 1309 matched control subjects. Levels of free testosterone and free oestradiol were calculated from absolute concentrations of …
引用总数
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R Kaaks, S Rinaldi, TJ Key, F Berrino, PHM Peeters… - Endocrine-related cancer, 2005