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Arsenic, a major environmental pollutant of global concern, is well-known for its reproductive toxicity. In this study, the protective potential of chlorogenic acid (CGA), a caffeoylquinic acid isomer abundantly found in many plants, was investigated against sodium arsenite (NaAsO₂)-induced testicular dysfunctions. Adult male Swiss mice were either administered NaAsO₂ alone at 5 mg kg⁻¹ or co-treated with CGA at 100 mg kg⁻¹ or 200 mg kg⁻¹ body weight for 4 weeks. Results showed that NaAsO₂-treated mice exhibited marked declines in testes weight, sperm count, and viability accompanied by decreases in sexual hormonal levels. Moreover, NaAsO₂ toxicity evoked exhaustion of antioxidant markers (SOD, CAT, GPx, GR, and GSH), down-regulation of Nrf2 (nuclear factor erythroid 2–related factor 2) gene expression level, and elevations in malondialdehyde. Further, elevations in inflammatory cytokines (IL-1 …