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Human norovirus (HNV) is a leading cause of viral gastroenteritis. Infection fails to elicit durable immunity and can cause chronic asymptomatic shedding. It is not known how norovirus escapes the adaptive immune response, and rigorous studies of the host and viral determinants underlying immune evasion are impeded by the lack of scalable cell culture systems and reverse genetic tools. Murine norovirus (MNV) recapitulates many aspects of HNV and enables studying norovirus biology in vitro and in vivo. MNV CW3 causes non-persistent infection with long-lasting immune memory, whereas MNV CR6 causes persistent infection despite inducing functional MNV-specific CD8+ T cells. We recently identified that MNV CR6 and other persistent MNV strains require tuft cells for chronic enteric infection. Tuft cells are rare, chemosensory epithelial cells with roles in pathogen surveillance, epithelial repair, and …