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Abstract A study of 13 male opiate addicts was undertaken to investigate the feasibility of transferring abruptly from methadone maintenance treatment to buprenorphine in an outpatient setting. The mean age of subjects was 30 years (range 18‐45) and all fulfilled DSM‐III‐R criteria for opioid dependence. All were maintained on a methadone dose of 20‐30 mg mixture daily and were transferred for 3 days to 4 mg buprenorphine sublingually 24‐26 hours after their last dose of methadone. On day 1 repeated measures of drug effects were performed, including agonist and withdrawal effects, and this was complemented by saccadic eye movements, a potential new measure of central opioid effects. These recordings were repeated once on days 2 and 3 and the subjects returned to their previous dose of methadone on day 4. Buprenorphine caused no detectable agonist effects or drug “high”, but had “good” effects …