作者
Magnus Ekström, Diana Ferreira, Sungwon Chang, Sandra Louw, Miriam J Johnson, Danny J Eckert, Belinda Fazekas, Katherine J Clark, Meera R Agar, David C Currow, Christine McDonald, John Miners, Carl Kirkpatrick, Andrew Somogyi, Linda Denehy, Nikki McCaffrey, Lawrence Lam, Aine Greene, Brian Le, Katherine Clark, Kwun Fong, Meera Agar, Rohit Joshi, Sharon Kilbreath, Angela Clow, Nina Smith, Richella Ryan, Sara Booth, Peter Martin, Suharsha Kanathigoda, Caitlin Sheehan, Jessica Lee, Peter Allcroft, Erica Cameron-Taylor, Philip Good, Louise Welch, Richard Chye, Jennifer Phillip, John Wheatley, Michael Epton, Rajesh Aggarwal, Philip McCloud, Jessie Chan, Douglas Bellamy, Frances Bellemore, Priyanka Bhatarai, Helen Biggins, Mary-Rose Birch, Lesley Burke, Tracey Burns, Naomi Byfieldt, Diana Charlesworth, Gillian Collins, Helen Cooper, Urska Cosic, Deborah Courtney, Georgie Cupples, Anna Dowd, Ruth Dunleavey, Terence Edgar, Amanda Fischer, Lisa Fuhrmeister, Jan Gesling, Rosetta Hart, Kim Hopkinson, Michelle Kaczurowski, Sally Kidd, Ngaire Kingi, Vera Margitanovic, Gillian McCarthy, Robin O'Reilly, Mary Perry, Bronwyn Raymond, Di Saward, Aaron Shanon-Honson, Karyn Sullivan, Michelle Tonkin, Zac Vandersman, Penny West, Julie Wilcock, Malina Storer, Sarah Nestor, Safrina Thristiawati, Manraaj Sidhu
发表日期
2022/11/22
期刊
Jama
卷号
328
期号
20
出版商
American Medical Association
简介
Importance
Chronic breathlessness is common in people with chronic obstructive pulmonary disease (COPD). Regular, low-dose, extended-release morphine may relieve breathlessness, but evidence about its efficacy and dosing is needed.
Objective
To determine the effect of different doses of extended-release morphine on worst breathlessness in people with COPD after 1 week of treatment.
Design, Setting, and Participants
Multicenter, double-blind, placebo-controlled randomized clinical trial including people with COPD and chronic breathlessness (defined as a modified Medical Research Council score of 3 to 4) conducted at 20 centers in Australia. People were enrolled between September 1, 2016, and November 20, 2019, and followed up through December 26, 2019.
Interventions
People were randomized 1:1:1 to 8 mg/d or 16 mg/d of oral extended-release morphine or placebo during week 1. At the start of …
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M Ekström, D Ferreira, S Chang, S Louw, MJ Johnson… - Jama, 2022