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Cleome gynandra is an abundantly available species and grows as a weed in common barren land and in crop fields throughout India. In all over the world in different countries it is used to treat many diseases in their traditional system and it is also used in various traditional culinary systems for its remarkable nutritional and antioxidant properties. In India alone it is used by the traditional healers for many diseases eg. epilepsy, irritable bowel syndrome and in protozoal and worm infections. The high protein and amino acids, minerals content of this plant can make this as a highly economically important that can be grown and cultivated easily. In this review article through various established facts regarding the medicinal applications of cleome gynadra has been cited regarding the Immunomodulator, Antioxidant, Anticarcinogenic, Analgesic properties etc. Analysing all these established properties cleome gynandra may be a promising drug in future. Taking into account the essential mineral content, free radical scavenging properties and polyphenolic content the possible antidiabetic drug from cleome has been discussed.