作者
Shir Lynn Lim, QI Gao, Ma Shwe Zin Nyunt, Lingli Gong, Josephine B Lunaria, May Li Lim, Audrey Ling, Carolyn Su-Ping Lam, Arthur Mark Richards, Lieng Hsi Ling, Tze Pin Ng
发表日期
2016/1/1
期刊
Journal of Alzheimer's Disease
卷号
50
期号
1
页码范围
27-40
出版商
IOS Press
简介
Background: Few studies have comprehensively evaluated the relationship between vascular disease and cognition of older adults without cardiac disease.
Objective: We explored the associations of structural atherosclerosis, vascular stiffness, and reactivity with global, memory, attention, language, visuospatial ability, and executive function in community-dwelling, non-demented older Asians without cardiac diseases.
Methods: Cognition was assessed by Mini-Mental State Examination (MMSE)(n= 308) and detailed neuropsychological tests (n= 155). Vascular measures included carotid intima-media thickness; aortic stiffness [carotid-femoral pulse wave velocity (CFPWV), aortic augmentation index (AI), and aortic pulse pressure (PP)]; carotid stiffness [elasticity modulus (Ep), beta index (), arterial compliance (AC), carotid AI]; and endothelial function [reactive hyperemia index (RHI)]. Multivariable analyses …
学术搜索中的文章
SL Lim, QI Gao, MSZ Nyunt, L Gong, JB Lunaria… - Journal of Alzheimer's Disease, 2016