作者
Grant Mair, Rüdiger von Kummer, Zoe Morris, Anders von Heijne, Nick Bradey, Lesley Cala, André Peeters, Andrew J Farrall, Alessandro Adami, Gillian Potter, Geoff Cohen, Peter AG Sandercock, Richard I Lindley, Joanna M Wardlaw, IST-3 Collaborative Group, IST-3 Collaborative Group, Peter Sandercock, Richard I Lindley, Joanna M Wardlaw, Colin Baigent, David Chadwick, Pippa Tyrrell, Gordon Lowe, Martin Dennis, Geoff Cohen, Karen Innes, Heather Goodare, Richard I Lindley, Graeme J Hankey, Karl Matz, Michael Brainin, Gord Gubitz, Stephen J Phillips, Stefano Ricci, Antonio Arauz, Eivind Berge, Karsten Bruins Slot, Anna Czlonkowska, Adam Kobayashi, Manuel Correia, Phillippe Lyrer, Stefan Engelter, Veronica Murray, Andreas Terent, Bo Norrving, Per Wester, Graham Venables, Joanna M Wardlaw, Andrew Farrall, Zoe Morris, Rüdiger von Kummer, Lesley Cala, Anders von Heijne, Alessandro Adami, Andre Peeters, Gillian Potter, Nick Bradey, Joanna M Wardlaw, Rüdiger von Kummer, Andrew Farrall, Robin Sellar, Alessandro Adami, Philip White, Andrew Demchuk, Matthew Adams, Grant Mair, Bernard Yan, G Venables, C Blank, H Bowler, C Doyle, K Endean, K Harkness, E Parker, M Randall, C Roffe, N Ahmad, A Arora, S Brammer, J Chembala, B Davies, S Ellis, E Epstein, K Finney, C Jackson, C Jadun, R Kinston, H Maguire, I Memon, I Natarajan, M Poulson, R Sanyal, S Sills, A Vreeburg, E Ward, P Sandercock, R Al-Shahi Salman, R Davenport, M Dennis, P Hand, S Hart, I Kane, S Keir, M MacLeod, L McKinlay, H Milligan, E Sandeman, J Stone, C Sudlow, P Taylor, J Wardlaw, C Warlow, W Whiteley, A Williams, M Brown, B Athwal, V Bassan, N Bhupathiraju, J Bowler, C Davie, D Doig, R Erande, S Gilbert, L Ginsberg, R Greenwood, S Gregoire, N Harding, N Losseff, R Luder, N Passeron, R Perry, P Rayson, R Simister, S Stone, D Werring, J Barrett, H Aitken, S Cherian, R Davis, S Downham, L Godd, V Gott, D Jose, V Little, D Lowe, L Luxford, M McGrory, P Owings, N Price, J Richards
发表日期
2016/1/12
期刊
Neurology
卷号
86
期号
2
页码范围
118-125
出版商
Lippincott Williams & Wilkins
简介
Objective
To investigate whether the location and extent of the CT hyperdense artery sign (HAS) at presentation affects response to IV alteplase in the randomized controlled Third International Stroke Trial (IST-3).
Methods
All prerandomization and follow-up (24–48 hours) CT brain scans in IST-3 were assessed for HAS presence, location, and extent by masked raters. We assessed whether HAS grew, persisted, shrank, or disappeared at follow-up, the association with 6-month functional outcome, and effect of alteplase. IST-3 is registered (ISRCTN25765518).
Results
HAS presence (vs absence) independently predicted poor 6-month outcome (increased Oxford Handicap Scale [OHS]) on adjusted ordinal regression analysis (odds ratio [OR] 0.66, p < 0.001). Outcome was worse in patients with more (vs less) extensive HAS (OR 0.61, p = 0.027) but not in proximal (vs distal) HAS (p = 0.420). Increasing age was …
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G Mair, R von Kummer, Z Morris, A von Heijne… - Neurology, 2016