作者
Minesh P Mehta, William R Shapiro, See C Phan, Radj Gervais, Christian Carrie, Pierre Chabot, Roy A Patchell, Michael J Glantz, Lawrence Recht, Corey Langer, Ranjan K Sur, Wilson H Roa, Marc A Mahe, Andre Fortin, Carsten Nieder, Christina A Meyers, Jennifer A Smith, Richard A Miller, Markus F Renschler
发表日期
2009/3/15
期刊
International Journal of Radiation Oncology* Biology* Physics
卷号
73
期号
4
页码范围
1069-1076
出版商
Elsevier
简介
PURPOSE
To determine the efficacy of motexafin gadolinium (MGd) in combination with whole brain radiotherapy (WBRT) for the treatment of brain metastases from non–small-cell lung cancer.
METHODS AND MATERIALS
In an international, randomized, Phase III study, patients with brain metastases from non–small-cell lung cancer were randomized to WBRT with or without MGd. The primary endpoint was the interval to neurologic progression, determined by a centralized Events Review Committee who was unaware of the treatment the patients had received.
RESULTS
Of 554 patients, 275 were randomized to WBRT and 279 to WBRT+MGd. Treatment with MGd was well tolerated, and 92% of the intended doses were administered. The most common MGd-related Grade 3+ adverse events included liver function abnormalities (5.5%), asthenia (4.0%), and hypertension (4%). MGd improved the interval to …
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MP Mehta, WR Shapiro, SC Phan, R Gervais, C Carrie… - International Journal of Radiation Oncology* Biology …, 2009