作者
A Rintala, F Matcham, M Radaelli, G Locafaro, S Simblett, C Barattieri di San Pietro, V Bulgari, P Burke, J Devonshire, J Weyer, T Wykes, G Comi, M Hotopf, I Myin-Germeys, the RADAR-CNS Consortium
发表日期
2019/9/1
来源
Journal of psychosomatic research
卷号
124
页码范围
109761
出版商
Elsevier
简介
Objective
To study depression, anxiety, suicide risk, and emotional health-related quality of life (HRQoL) in people with clinically isolated syndrome (CIS) and in early phase multiple sclerosis (MS).
Methods
A systematic literature review was conducted with inclusion criteria of observational studies on outcomes of depression, anxiety, suicide risk, and emotional HRQoL in CIS and within five years since diagnosis of MS. Studies were screened using the Preferred Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, and study quality was determined for included studies. Meta-analysis and meta-regression were performed if applicable.
Results
Fifty-one studies were included in the systematic review. In early phase MS, meta-analyses of the Hospital Anxiety Depression Scale (HADS) indicated prevalence levels of 17% (95% confidence interval (CI): 9 to 25%; p < .001) for depressive and 35% (95% CI …
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A Rintala, F Matcham, M Radaelli, G Locafaro… - Journal of psychosomatic research, 2019