作者
Jing Zou, Chaitanya Kurhade, Hongjie Xia, Mingru Liu, Xuping Xie, Ping Ren, Pei-Yong Shi
发表日期
2022/5/26
期刊
Nature communications
卷号
13
期号
1
页码范围
2956
出版商
Nature Publishing Group UK
简介
The Omicron SARS-CoV-2 has several distinct sublineages, among which sublineage BA.1 is responsible for the initial Omicron surge and is now being replaced by BA.2 worldwide, whereas BA.3 is currently at a low frequency. The ongoing BA.1-to-BA.2 replacement underscores the importance to understand the cross-neutralization among the three Omicron sublineages. Here we test the neutralization of BA.1-infected human sera against BA.2, BA.3, and USA/WA1-2020 (a strain isolated in late January 2020). The BA.1-infected sera neutralize BA.1, BA.2, BA.3, and USA/WA1-2020 SARS-CoV-2s with geometric mean titers (GMTs) of 445, 107, 102, and 16, respectively. Thus, the neutralizing GMTs against heterologous BA.2, BA.3, and USA/WA1-2020 are 4.2-, 4.4-, and 28.4-fold lower than the GMT against homologous BA.1, respectively. These findings have implications in COVID-19 vaccine strategy.
引用总数
学术搜索中的文章
J Zou, C Kurhade, H Xia, M Liu, X Xie, P Ren, PY Shi - Nature communications, 2022