作者
L Hanson, L Tuzzio, J Fraser, E Larson, H Husby, J Delatorre-Reimer, F Refai, X Yan, K MacDonald, J Jones, M Gbotoe, K Knobel, K Sanchez, V Fitzpatrick, A Rivelli, B Chicoine, N Glowacki, R Khatib, X Xu, W Knapp, S Das, A Sturzu, K Buss, K Miller, E Weirich, K Sivanesan, J Smucny, M MacMillan, A Lopez, S Nichols, D Chung, K McCall, B Piper, C Wood, L Bailey-Davis, A Ramasamy, N Iyer, G Smolarz, J Mowery, A Cook, P Benotti, C Still, C Fiordalisi, K Ley, A Borsky, C Gordon, S Chang, J An, J Sim, R Liu, R Wei, H Zhou, K Reynolds, J Hao, N Chen, D Hassen, T Klinger, M McMinn, D Hartzel, D Veenstra, S Spencer, M Williams, S Snyder, J Peterson, V Schlieder, L Jones, A Chang, H Bonaparte, C Yule, A Naylor, S Kwiecien, M Taher, A Nale, S Juraschek, C Collins, C Rogers, S Voyce, P Roman, J Chronowski, E Wright, M Gionfriddo, E Kowalek, D Kuhn, A Boyer, L Hoque, A Amroze, V Gilvaz, S Abraham, A Lal, A Mishra, S Crawford, K Mazor, D McManus, A Kapoor, J Quiambao, L Clowers, D Currier-Kirby, M Jamshidi, H Mohammmad, S Gilhooley, J Lewis, K Cope, S Birken, E Haines, S Hwang, D Chambers, A Bunger, M Harrison, P Nilsen, J Ziegenfuss, L Solberg, S Asche, E Grossman, C Norton, K Williams, B Wilson, C Jurkovitz, J Melson, J Reitz, C Pal, S Hausman, E Booker, L Lang, T Horton, J Boggs, L Quintana, A Beck, S Clinich, L Richardson, A Conley, J Hardee, M Betz, K Margolis, A Crain, B Green, P O’Connor, M Beran, A Bergdall, P Pawloski, A Kodet, D Rehrauer, Z McKinney, P Haugen, J Anderson, B Crabtree, N Trower, D Appana, R Sharma, S Norman, J Sperl-Hillen
发表日期
2020/1/1
期刊
Journal of Patient-centered Research and Reviews
卷号
7
期号
1
页码范围
64-137
简介
Background
More than 5 million Americans are living with Alzheimer’s disease or a related dementia, and that number is expected to triple in the next three decades. People with dementia (PWD) have higher rates of hospital stays, emergency room visits, skilled nursing facility stays, and overall health care utilization. Caregivers of PWD experience increased anxiety, depression, and stress. It is imperative that health systems address this large and growing unmet need to improve symptom management for PWD and minimize caregiver strain. A disconnect between research evidence showing that nonpharmacologic interventions improve outcomes for PWD and their caregivers and real-world health care systems has stymied the adoption of promising interventions. Embedded pragmatic clinical trials (ePCTs) have the potential to accelerate the translation of evidence-based interventions into clinical practice.
Methods
The mission of the National Institute on Aging (NIA) IMPACT Collaboratory is to build the nation’s capacity to conduct pragmatic clinical trials of nonpharmacologic interventions embedded within health care systems for PWD and their caregivers. Through 6 administrative and management teams and 10 working group cores, IMPACT aims to develop and disseminate best practice research methods, support the design and conduct of pragmatic trials (including funding of pilot studies), build investigator capacity through training and knowledge generation, catalyze collaboration among stakeholders including health care providers and investigators, and ensure culturally tailored interventions and engagement of people from diverse and …
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L Hanson, L Tuzzio, J Fraser, E Larson, H Husby… - Journal of Patient-centered Research and Reviews, 2020