作者
Omer Kucuk, Fazlul H Sarkar, Zora Djuric, Wael Sakr, Michael N Pollak, Fred Khachik, Mousumi Banerjee, John S Bertram, David P Wood Jr
发表日期
2002/11
期刊
Experimental Biology and Medicine
卷号
227
期号
10
页码范围
881-885
出版商
SAGE Publications
简介
Epidemiological studies have shown an inverse association between dietary intake of lycopene and prostate cancer risk. We conducted a clinical trial to investigate the biological and clinical effects of lycopene supplementation in patients with localized prostate cancer. Twenty-six men with newly diagnosed prostate cancer were randomly assigned to receive a tomato oleoresin extract containing 30 mg of lycopene (n = 15) or no supplementation (n = 11) for 3 weeks before radical prostatectomy. Biomarkers of cell proliferation and apoptosis were assessed by Western blot analysis in benign and cancerous prostate tissues. Oxidative stress was assessed by measuring the Peripheral blood lymphocyte ONA oxidation product 5-hydroxymethyl-deoxyuridine (5-OH-mdU). Usual dietary Intake of nutrients was assessed by a food frequency questionnaire at baseline. Prostatectomy specimens were evaluated for pathologic …
引用总数
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