作者
Daisuke Izumi, Takatsugu Ishimoto, Keisuke Miyake, Hidetaka Sugihara, Kojiro Eto, Hiroshi Sawayama, Tadahito Yasuda, Yuki Kiyozumi, Takayoshi Kaida, Junji Kurashige, Yu Imamura, Yukiharu Hiyoshi, Masaaki Iwatsuki, Shiro Iwagami, Yoshifumi Baba, Yasuo Sakamoto, Yuji Miyamoto, Naoya Yoshida, Masayuki Watanabe, Hiroshi Takamori, Norie Araki, Patrick Tan, Hideo Baba
发表日期
2016/3/1
期刊
International journal of cancer
卷号
138
期号
5
页码范围
1207-1219
简介
Cancer‐associated fibroblasts (CAFs) are reportedly involved in invasion and metastasis in several types of cancer, including gastric cancer (GC), through the stimulation of CXCL12/CXCR4 signaling. However, the mechanisms underlying these tumor‐promoting effects are not well understood, which limits the potential to develop therapeutic targets against CAF‐mediated CXCL12/CXCR4 signaling. CXCL12 expression was analyzed in resected GC tissues from 110 patients by immunohistochemistry (IHC). We established primary cultures of normal fibroblasts (NFs) and CAFs from the GC tissues and examined the functional differences between these primary fibroblasts using co‐culture assays with GC cell lines. We evaluated the efficacy of a CXCR4 antagonist (AMD3100) and a FAK inhibitor (PF‐573,228) on the invasive ability of GC cells. High CXCL12 expression levels were significantly associated with larger …
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D Izumi, T Ishimoto, K Miyake, H Sugihara, K Eto… - International journal of cancer, 2016