作者
Javier Escaned, Mauro Echavarría-Pinto, Hector M Garcia-Garcia, Tim P Van De Hoef, Ton De Vries, Prashant Kaul, Ganesh Raveendran, John D Altman, Howard I Kurz, Johannes Brechtken, Mark Tulli, Clemens Von Birgelen, Joel E Schneider, Ahmed A Khashaba, Allen Jeremias, Jim Baucum, Raul Moreno, Martijn Meuwissen, Gregory Mishkel, Robert-Jan van Geuns, Howard Levite, Ramon Lopez-Palop, Marc Mayhew, Patrick W Serruys, Habib Samady, Jan J Piek, Amir Lerman, ADVISE II Study Group
发表日期
2015/5/1
期刊
Cardiovascular interventions
卷号
8
期号
6
页码范围
824-833
出版商
American College of Cardiology Foundation
简介
Objectives
The purpose of this study was to assess the diagnostic accuracy of the instantaneous wave-free ratio (iFR) to characterize, outside of a pre-specified range of values, stenosis severity, as defined by fractional flow reserve (FFR) ≤0.80, in a prospective, independent, controlled, core laboratory–based environment.
Background
Studies with methodological heterogeneity have reported some discrepancies in the classification agreement between iFR and FFR. The ADVISE II (ADenosine Vasodilator Independent Stenosis Evaluation II) study was designed to overcome limitations of previous iFR versus FFR comparisons.
Methods
A total of 919 intermediate coronary stenoses were investigated during baseline and hyperemia. From these, 690 pressure recordings (n = 598 patients) met core laboratory physiology criteria and are included in this report.
Results
The pre-specified iFR cut-off of 0.89 was …
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J Escaned, M Echavarría-Pinto, HM Garcia-Garcia… - Cardiovascular interventions, 2015
