作者
Mohamed Nabil Elshafei, Ahmed El‐Bardissy, Ahmed Khalil, Mohammed Danjuma, Mahmood Mubasher, Ibrahim Y Abubeker, Mouhand FH Mohamed
发表日期
2021/9
来源
European journal of clinical investigation
卷号
51
期号
9
页码范围
e13645
简介
Background
Colchicine was recently repurposed for the management of coronavirus disease 2019 (COVID‐19). This rapid review and meta‐analysis aimed to assess colchicine's impact on mortality outcomes in COVID‐19 patients.
Materials and Methods
We systematically searched PubMed, EMBASE, Google Scholar since their inception till 25/03/2021 for observational or controlled studies that reported mortality as an outcome. The mortality odd ratios were generated with their corresponding 95% confidence intervals utilizing the random‐effects model.
Results
Nine studies comprising 5522 patients met our inclusion criteria. Our meta‐analysis revealed significantly lower mortality in the colchicine group (OR 0.35, 95% CI 0.25‐0.48, I2 0%) compared with controls. A subgroup analysis limited to hospitalized patients (OR 0.35, 95% CI 0.25‐0.50, I2 0%) revealed similarly lower mortality in the colchicine group …
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MN Elshafei, A El‐Bardissy, A Khalil, M Danjuma… - European journal of clinical investigation, 2021
