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In this study, we propose a set of new algorithms to enhance the effectiveness of classification for 5-year survivability of breast cancer patients from a massive data set with imbalanced property. The proposed classifier algorithms are a combination of synthetic minority oversampling technique (SMOTE) and particle swarm optimization (PSO), while integrating some well known classifiers, such as logistic regression, C5 decision tree (C5) model, and 1-nearest neighbor search. To justify the effectiveness for this new set of classifiers, the g-mean and accuracy indices are used as performance indexes; moreover, the proposed classifiers are compared with previous literatures. Experimental results show that the hybrid algorithm of SMOTE + PSO + C5 is the best one for 5-year survivability of breast cancer patient classification among all algorithm combinations. We conclude that, implementing SMOTE in appropriate …