作者
Farida Sohrabji, Rajesh C Miranda, C Dominique Toran-Allerand
发表日期
1994/2/1
期刊
Journal of Neuroscience
卷号
14
期号
2
页码范围
459-471
出版商
Society for Neuroscience
简介
We have previously shown that neurons in the basal forebrain colocalize the neurotrophin receptor p75NGFR and estrogen receptors. The present study was designed to examine (1) if neural neurotrophin targets respond to estrogen as a general phenotypic feature and (2) if NGF receptor mRNAs are regulated by estrogen, using a prototypical target of NGF, the dorsal root ganglion (DRG) (sensory) neuron. We demonstrate, for the first time, the presence of estrogen receptor mRNA and protein (binding sites) in adult female rat DRG. Moreover, estrogen receptor mRNA expression, while present in DRG neurons from both the ovariectomized (OVX; estrogen deficient) and intact female rat, was downregulated, as in the adult CNS, during proestrus (high estrogen levels) and in OVX animals replaced with proestrus levels of estrogen, as compared to OVX controls. In contrast, although the mRNAs for the NGF receptors …
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F Sohrabji, RC Miranda, CD Toran-Allerand - Journal of Neuroscience, 1994