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Inflammatory Bowel Diseases (IBD), to which Crohn’s Disease (CD) and Ulcerative Colitis (UC) belong, are chronic digestive disorders with a natural history of remittingrecurrent course that can directly impact the patient’s quality of life. UC is limited to the colon and rectum with continuous and non-transmural involvement while CD has a much more complex disease topography as it can affect the entire gastrointestinal tract from the mouth to the anus with discontinuous and transmural involvement. IBD are associated with numerous extra-intestinal manifestations (such as articular, ocular, cutaneous, urogenital, and cardiorespiratory) that greatly complicate the basic clinical picture resulting in a disease phenotype that can be extremely varied. Treatment relies on pharmacological, nutritional even surgical interventions. Often the patient, in case of intolerance or failure of conventional therapy or in case of dependence or refractoriness to steroid therapy, undergoes immunosuppressive therapy also with biologic drugs. The latter have positively revolutionized the prognosis and course of IBD. However, IBD patients on immunosuppressive therapy are exposed to a wide range of infectious agents for which appropriate preventive measures are recommended, even considering the incipient Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) pandemic. The purpose of this Research Topic was to gather new evidence on the complex needs of patients with IBD.