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Corrugating channel walls is a way to enhance heat transfer in heat exchangers. In the current investigation, the entropy generation minimization approach has been employed to optimize heat transfer and fluid flow within a wavy channel. A numerical method has been built to compute entropy generation rate in a sinusoidal wavy-wall channel with copper-water (Cu-water) nanofluid flow. The governing equations have been discretized using finite volume method for a two-dimensional steady flow. The effects of geometrical and flow parameters, including nanoparticles volume fraction (0.01 < ϕ < 0.05), Richardson number (0.1 < Ri < 10), wave amplitude ratio (0.1 < α < 0.3) and wave length ratio (1 < λ < 3), have been investigated. Results reveal that increasing nanoparticle volume fraction within investigated Richardson number will increase Nusselt number. In addition, the maximum entropy …