作者
Andrea S Foulkes, Caitlin Selvaggi, Daniel Shinnick, Heidi Lumish, Eunyoung Kim, Tingyi Cao, Tanayott Thaweethai, Jing Qian, Frances Lu, Joyce Yan, David Cheng, Wei He, Kevin J Clerkin, Mahesh V Madhavan, James B Meigs, Virginia A Triant, Steven A Lubitz, Aakriti Gupta, Ingrid V Bassett, Muredach P Reilly
发表日期
2022/2
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
107
期号
2
页码范围
e698-e707
出版商
Oxford University Press
简介
Background
Obesity is an established risk factor for severe COVID-19 outcomes. The mechanistic underpinnings of this association are not well-understood.
Objective
To evaluate the mediating role of systemic inflammation in obesity-associated COVID-19 outcomes.
Methods
This hospital-based, observational study included 3828 SARS-CoV-2-infected patients who were hospitalized February to May 2020 at Massachusetts General Hospital (MGH) or Columbia University Irving Medical Center/New York Presbyterian Hospital (CUIMC/NYP). We use mediation analysis to evaluate whether peak inflammatory biomarkers (C-reactive protein [CRP], erythrocyte sedimentation rate [ESR], D-dimer, ferritin, white blood cell count and interleukin-6) are in the causal pathway between obesity (BMI ≥ 30) and mechanical ventilation or death within 28 days of …
学术搜索中的文章
AS Foulkes, C Selvaggi, D Shinnick, H Lumish, E Kim… - The Journal of Clinical Endocrinology & Metabolism, 2022