作者
Rachele Invernizzi, Benjamin G Wu, Joseph Barnett, Poonam Ghai, Shaun Kingston, Richard J Hewitt, Johanna Feary, Yonghua Li, Felix Chua, Zhe Wu, Athol U Wells, Peter M George, Elisabetta A Renzoni, Andrew G Nicholson, Alexandra Rice, Anand Devaraj, Leopoldo N Segal, Adam J Byrne, Toby M Maher, Clare M Lloyd, Philip L Molyneaux
发表日期
2021/2/1
期刊
American Journal of Respiratory and Critical Care Medicine
卷号
203
期号
3
页码范围
339-347
出版商
American Thoracic Society
简介
Rationale: Chronic hypersensitivity pneumonitis (CHP) is a condition that arises after repeated exposure and sensitization to inhaled antigens. The lung microbiome is increasingly implicated in respiratory disease, but, to date, no study has investigated the composition of microbial communities in the lower airways in CHP.
Objectives: To characterize and compare the airway microbiome in subjects with CHP, subjects with idiopathic pulmonary fibrosis (IPF), and control subjects.
Methods: We prospectively recruited individuals with a CHP diagnosis (n = 110), individuals with an IPF diagnosis (n = 45), and control subjects (n = 28). Subjects underwent BAL and bacterial DNA was isolated, quantified by quantitative PCR and the 16S ribosomal RNA gene was sequenced to characterize the bacterial communities in the lower airways.
Measurements and Main Results: Distinct differences in the microbial profiles …
学术搜索中的文章
R Invernizzi, BG Wu, J Barnett, P Ghai, S Kingston… - American Journal of Respiratory and Critical Care …, 2021