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The security and privacy concerns along with the amount of data that is required to be processed on regular basis has pushed processing to the edge of the computing systems. Deploying advanced Neural Networks (NN), such as deep neural networks (DNNs) and spiking neural networks (SNNs), that offer state-of-the-art results on resource-constrained edge devices is challenging due to the stringent memory and power/energy constraints. Moreover, these systems are required to maintain correct functionality under diverse security and reliability threats. This paper first discusses existing approaches to address energy efficiency, reliability, and security issues at different system layers, i.e., hardware (HW) and software (SW). Afterward, we discuss how to further improve the performance (latency) and the energy efficiency of Edge AI systems through HW/SW-level optimizations, such as pruning, quantization, and …