作者
Anita M van den Hoek, José W A van der Hoorn, AC Maas, RM van den Hoogen, A van Nieuwkoop, S Droog, EH Offerman, EJ Pieterman, LM Havekes, HMG Princen
发表日期
2014/6
期刊
Diabetes, Obesity and Metabolism
卷号
16
期号
6
页码范围
537-544
出版商
Blackwell Publishing Ltd
简介
Aims
This study aimed to investigate systematically (i) the appropriate dietary conditions to induce the features of the MetS in APOE*3Leiden.humanCholesteryl Ester Transfer Protein (E3L.CETP) mice and (ii) whether the response of this model to different antidiabetic and hypolipidemic drugs is similar as in humans.
Methods
Male obese, IR and dyslipidemic E3L.CETP mice were treated with antidiabetic drugs rosiglitazone, liraglutide or an experimental 11β‐hydroxysteroid‐dehydrogenase‐1 (HSD‐1) inhibitor, or with hypolipidemic drugs atorvastatin, fenofibrate or niacin for 4–6 weeks. The effects on bw, IR and plasma and liver lipids were assessed.
Results
Rosiglitazone, liraglutide and HSD‐1 inhibitor significantly decreased glucose and insulin levels or IR. Liraglutide and HSD‐1 inhibitor also decreased bw. Atorvastatin, fenofibrate and niacin improved the dyslipidemia and fenofibrate and niacin increased …
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AM van den Hoek, JWA van der Hoorn, AC Maas… - Diabetes, Obesity and Metabolism, 2014