作者
Pardis C Sabeti, Patrick Varilly, Ben Fry, Jason Lohmueller, Elizabeth Hostetter, Chris Cotsapas, Xiaohui Xie, Elizabeth H Byrne, Steven A McCarroll, Rachelle Gaudet, Stephen F Schaffner, Eric S Lander, International HapMap Consortium Genotyping centres: Perlegen Sciences Frazer Kelly A.(Principal Investigator) 7 Ballinger Dennis G. 8 Cox David R. 8 Hinds David A. 8 Stuve Laura L. 8, Baylor College of Medicine and ParAllele BioScience Gibbs Richard A.(Principal Investigator) 9 Belmont John W. 9 Boudreau Andrew 10 Hardenbol Paul 11 Leal Suzanne M. 9 Pasternak Shiran 12 Wheeler David A. 9 Willis Thomas D. 10 Yu Fuli 13, Chinese National Human Genome Center at Beijing Shen Yan (Principal Investigator) 16 Yao Zhijian 16, Chinese National Human Genome Center at Shanghai Huang Wei (Principal Investigator) 17 Chu Xun 17 He Yungang 17 Jin Li 18 Liu Yangfan 17 Shen Yayun 17 Sun Weiwei 17 Wang Haifeng 17 Wang Yi 17 Wang Ying 17 Xiong Xiaoyan 17 Xu Liang 17, Chinese University of Hong Kong Waye Mary MY (Principal Investigator) 19 Tsui Stephen KW 19, Hong Kong University of Science and Technology Xue Hong 20 Tze-Fei Wong J. 20, Illumina Galver Luana M.(Project Leader) 21 Fan Jian-Bing 21 Gunderson Kevin 21 Murray Sarah S. 7 Oliphant Arnold R. 22 Chee Mark S.(Principal Investigator) 23, University of California at San Francisco and Washington University Kwok Pui-Yan 27 Cai Dongmei 27 Koboldt Daniel C. 28 Miller Raymond D. 28 Pawlikowska Ludmila 27 Taillon-Miller Patricia 28 Xiao Ming 27, University of Hong Kong Tsui Lap-Chee (Principal Investigator) 29 Mak William 29 Qiang Song You 29 Tam Paul KH 29, University of Tokyo and RIKEN Nakamura Yusuke (Principal Investigator) 30 31 Kawaguchi Takahisa 31 Kitamoto Takuya 31 Morizono Takashi 31 Nagashima Atsushi 31 Ohnishi Yozo 31 Sekine Akihiro 31 Tanaka Toshihiro 31 Tsunoda Tatsuhiko 31, Cold Spring Harbor Laboratory Stein Lincoln D.(Principal Investigator) 12 Krishnan Lalitha 12 Vernon Smith Albert 12 Tello-Ruiz Marcela K. 12 Thorisson Gudmundur A. 36, Johns Hopkins University School of Medicine Chakravarti Aravinda 37 Chen Peter E. 37 Cutler David J. 37 Kashuk Carl S. 37 Lin Shin 37, University of Michigan Abecasis Gonçalo R.(Principal Investigator) 38 Guan Weihua 38 Li Yun 38 Munro Heather M. 39 Qin Zhaohui Steve 38 Thomas Daryl J. 40, University of Oxford McVean Gilean (Project Leader) 41 Auton Adam 41 Bottolo Leonardo 41 Cardin Niall 41 Eyheramendy Susana 41 Freeman Colin 41 Marchini Jonathan 41 Myers Simon 41 Spencer Chris 13 Stephens Matthew 42 Donnelly Peter 41, University of Oxford, Wellcome Trust Centre for Human Genetics Cardon Lon R.(Principal Investigator) 43 Clarke Geraldine 44 Evans David M. 44 Morris Andrew P. 44 Weir Bruce S. 45, RIKEN Tsunoda Tatsuhiko (Principal Investigator) 31 Johnson Todd A 31, US National Institutes of Health Mullikin James C. 46, US National Institutes of Health National Center for Biotechnology Information Sherry Stephen T. 47 Feolo Michael 47 Skol Andrew 48, Community engagement/public consultation and sample collection groups: Beijing Normal University and Beijing Genomics Institute Zhang Houcan 49 Zeng Changqing 14 Zhao Hui 14, Health Sciences University of Hokkaido, Eubios Ethics Institute and Shinshu University Matsuda Ichiro (Principal Investigator) 50 Fukushima Yoshimitsu 51 Macer Darryl R. 52 Suda Eiko 53, Howard University and University of Ibadan Rotimi Charles N.(Principal Investigator) 54 Adebamowo Clement A. 55 Ajayi Ike 55 Aniagwu Toyin 55 Marshall Patricia A. 56 Nkwodimmah Chibuzor 55 Royal Charmaine DM 54, University of Utah Leppert Mark F.(Principal Investigator) 57 Dixon Missy 57 Peiffer Andy 57, Ethical, legal and social issues: Chinese Academy of Social Sciences Qiu Renzong 58, Genetic Interest Group Kent Alastair 59, Kyoto University Kato Kazuto 60, Nagasaki University Niikawa Norio 61, University of Ibadan School of Medicine Adewole Isaac F. 55, University of Montréal Knoppers Bartha M. 25, University of Oklahoma Foster Morris W. 62, Vanderbilt University Clayton Ellen Wright 63, Wellcome Trust Watkin Jessica 64, SNP discovery: Baylor College of Medicine Gibbs Richard A.(Principal Investigator) 9 Belmont John W. 9 Muzny Donna 9 Nazareth Lynne 9 Sodergren Erica 9 Weinstock George M. 9 Wheeler David A. 9 Yakub Imtaz 9, Broad Institute of Harvard and Massachusetts Institute of Technology Gabriel Stacey B.(Project Leader) 13 Onofrio Robert C. 13 Richter Daniel J. 13 Ziaugra Liuda 13 Birren Bruce W. 13 Daly Mark J. 13 15 Altshuler David (Principal Investigator) 13 15 65, Washington University Wilson Richard K. 65 Fulton Lucinda L. 65, Wellcome Trust Sanger Institute Rogers Jane (Principal Investigator) 32 Burton John 32 Carter Nigel P. 32 Clee Christopher M. 32 Griffiths Mark 32 Jones Matthew C. 32 McLay Kirsten 32 Plumb Robert W. 32 Ross Mark T. 32 Sims Sarah K. 32 Willey David L. 32, Scientific management: Chinese Academy of Sciences Chen Zhu 66 Han Hua 66 Kang Le 66, Genome Canada Godbout Martin 67 Wallenburg John C. 68, Génome Québec L'Archevêque Paul 69 Bellemare Guy 69, Japanese Ministry of Education, Culture, Sports, Science and Technology Saeki Koji 71, Ministry of Science and Technology of the People’s Republic of China Wang Hongguang 71 An Daochang 71 Fu Hongbo 71 Li Qing 71 Wang Zhen 71, Human Genetic Resource Administration of China Wang Renwu 73, SNP Consortium Holden Arthur L. 21, US National Institutes of Health Brooks Lisa D. 73 McEwen Jean E. 73 Guyer Mark S. 73 Ota Wang Vivian 73 74 Peterson Jane L. 73 Shi Michael 75 Spiegel Jack 76 Sung Lawrence M. 77 Zacharia Lynn F. 73 Collins Francis S. 78, Wellcome Trust Kennedy Karen 67 Jamieson Ruth 64 Stewart John 64
发表日期
2007/10/18
期刊
Nature
卷号
449
期号
7164
页码范围
913-918
出版商
Nature Publishing Group UK
简介
With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms from the International HapMap Project Phase 2 (HapMap2). We used ‘long-range haplotype’ methods, which were developed to identify alleles segregating in a population that have undergone recent selection, and we also developed new methods that are based on cross-population comparisons to discover alleles that have swept to near-fixation within a population. The analysis reveals more than 300 strong candidate regions. Focusing on the strongest 22 regions, we develop a heuristic for scrutinizing these regions to identify candidate targets of selection. In a complementary analysis, we identify 26 non-synonymous, coding, single nucleotide polymorphisms showing regional evidence of positive selection …
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