作者
Nigel B Jamieson, Mohamed Mohamed, Karin A Oien, Alan K Foulis, Euan J Dickson, Clem W Imrie, C Ross Carter, Colin J McKay, Donald C McMillan
发表日期
2012/10
期刊
Annals of surgical oncology
卷号
19
页码范围
3581-3590
出版商
Springer-Verlag
简介
Background
The tumor-associated inflammatory cell infiltrate is recognized to have prognostic value in various common solid tumors. However, the prognostic value of the tumor inflammatory cell infiltrate has not been established in pancreatic ductal adenocarcinoma (PDAC) nor has its relationship with the systemic inflammatory response.
Methods
Retrospective study was made of 173 patients who underwent surgery between 1997 and 2009. Routine pathology specimens were scored according to density of the tumor inflammatory cell infiltrate, and biochemical data were collected preoperatively.
Results
Low-grade tumor inflammatory cell infiltrate was associated with earlier tumor recurrence (P < 0.001) and particularly in the liver (P = 0.027). It was also associated with T3 tumors (P < 0.05), lymph node involvement (P …
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NB Jamieson, M Mohamed, KA Oien, AK Foulis… - Annals of surgical oncology, 2012