作者
Vivian G Loo, Anne-Marie Bourgault, Louise Poirier, François Lamothe, Sophie Michaud, Nathalie Turgeon, Baldwin Toye, Axelle Beaudoin, Eric H Frost, Rodica Gilca, Paul Brassard, Nandini Dendukuri, Claire Béliveau, Matthew Oughton, Ivan Brukner, Andre Dascal
发表日期
2011/11/3
期刊
New England Journal of Medicine
卷号
365
期号
18
页码范围
1693-1703
出版商
Massachusetts Medical Society
简介
Background
Clostridium difficile infection is the leading cause of health care–associated diarrhea, and the bacterium can also be carried asymptomatically. The objective of this study was to identify host and bacterial factors associated with health care–associated acquisition of C. difficile infection and colonization.
Methods
We conducted a 15-month prospective study in six Canadian hospitals in Quebec and Ontario. Demographic information, known risk factors, potential confounding factors, and weekly stool samples or rectal swabs were collected. Pulsed-field gel electrophoresis (PFGE) was performed on C. difficile isolates to determine the genotype. Levels of serum antibodies against C. difficile toxins A and B were measured.
Results
A total of 4143 patients were included in the study; 117 (2.8%) and 123 (3.0%) had health care–associated C. difficile infection and colonization, respectively. Older age and use …
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VG Loo, AM Bourgault, L Poirier, F Lamothe… - New England Journal of Medicine, 2011
