作者
Vivian G Loo, Louise Poirier, Mark A Miller, Matthew Oughton, Michael D Libman, Sophie Michaud, Anne-Marie Bourgault, Tuyen Nguyen, Charles Frenette, Mirabelle Kelly, Anne Vibien, Paul Brassard, Susan Fenn, Ken Dewar, Thomas J Hudson, Ruth Horn, Pierre René, Yury Monczak, André Dascal
发表日期
2005/12/8
期刊
New England Journal of Medicine
卷号
353
期号
23
页码范围
2442-2449
出版商
Massachusetts Medical Society
简介
Background
In March 2003, several hospitals in Quebec, Canada, noted a marked increase in the incidence of Clostridium difficile–associated diarrhea.
Methods
In 2004 we conducted a prospective study at 12 Quebec hospitals to determine the incidence of nosocomial C. difficile–associated diarrhea and its complications and a case–control study to identify risk factors for the disease. Isolates of C. difficile were typed by pulsed-field gel electrophoresis and analyzed for binary toxin genes and partial deletions in the toxin A and B repressor gene tcdC. Antimicrobial susceptibility was evaluated in a subgroup of isolates.
Results
A total of 1703 patients with 1719 episodes of nosocomial C. difficile–associated diarrhea were identified. The incidence was 22.5 per 1000 admissions. The 30-day attributable mortality rate was 6.9 percent. Case patients were more likely than matched controls to have received …
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VG Loo, L Poirier, MA Miller, M Oughton, MD Libman… - New England Journal of Medicine, 2005