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OBJECTIVES:

Systemic corticosteroids are among the most common anti-inflammatory treatments in elderly-onset inflammatory bowel disease (IBD) patients. Steroid use and older age each independently predisposes to infections, and infections increase mortality in hospitalized older IBD patients. Therefore, our objective was to examine the risk of serious infections in elderly-onset IBD patients treated with oral corticosteroids, and explore how the timing of exposure affects the risk estimates.

METHODS:

Using the health-care databases of the province of Quebec, Canada, we conducted a population-based cohort study with a nested case–control analysis. Incident IBD patients aged≥ 66 years were identified. Conditional logistic regression was performed to estimate crude and adjusted rate ratios (aRRs) with 95% confidence intervals (CIs).

RESULTS:

We identified 3,522 elderly-onset patients, of which 564 cases …