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The aim of this study is to investigate the antibacterial activity of aluminium oxide nanoparticles (Al₂O₃ NPs) against multidrug‐resistant clinical isolates of Escherichia coli and their interaction with cell envelope biomolecules.

Al₂O₃ NPs were characterized by scanning electron microscope (SEM), high‐resolution transmission electron microscope (HR‐TEM) and X‐ray diffraction (XRD) analyses. Antibacterial activity and interaction of Al₂O₃ NPs with E. coli and its surface biomolecules were assessed by spectrophotometry, SEM, HR‐TEM and attenuated total reflectance/Fourier transform infrared (ATR‐FTIR). Of the 80 isolates tested, about 64 (80%) were found to be extended spectrum β‐lactamase (ESBL) positive and 16 (20%) were non‐ESBL producers. Al₂O₃ NPs at 1000 μg ml⁻¹ significantly inhibited the bacterial growth. SEM and HR‐TEM …