作者
Ying Jin, Stanca A Birlea, Pamela R Fain, Katherine Gowan, Sheri L Riccardi, Paulene J Holland, Christina M Mailloux, Alexandra JD Sufit, Saunie M Hutton, Anita Amadi-Myers, Dorothy C Bennett, Margaret R Wallace, Wayne T McCormack, E Helen Kemp, David J Gawkrodger, Anthony P Weetman, Mauro Picardo, Giovanni Leone, Alain Taïeb, Thomas Jouary, Khaled Ezzedine, Nanny van Geel, Jo Lambert, Andreas Overbeck, Richard A Spritz
发表日期
2010/5/6
期刊
New England Journal of Medicine
卷号
362
期号
18
页码范围
1686-1697
出版商
Massachusetts Medical Society
简介
Background
Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair, and is associated with an elevated risk of other autoimmune diseases.
Methods
To identify generalized vitiligo susceptibility loci, we conducted a genomewide association study. We genotyped 579,146 single-nucleotide polymorphisms (SNPs) in 1514 patients with generalized vitiligo who were of European-derived white (CEU) ancestry and compared the genotypes with publicly available control genotypes from 2813 CEU persons. We then tested 50 SNPs in two replication sets, one comprising 677 independent CEU patients and 1106 CEU controls and the other comprising 183 CEU simplex trios with generalized vitiligo and 332 CEU multiplex families.
Results
We detected significant associations between generalized vitiligo and SNPs at several loci previously …
引用总数
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Y Jin, SA Birlea, PR Fain, K Gowan, SL Riccardi… - New England Journal of Medicine, 2010