作者
David E Kandzari, Michael Böhm, Felix Mahfoud, Raymond R Townsend, Michael A Weber, Stuart Pocock, Konstantinos Tsioufis, Dimitrios Tousoulis, James W Choi, Cara East, Sandeep Brar, Sidney A Cohen, Martin Fahy, Garrett Pilcher, Kazuomi Kario, Jiro Aoki, Bryan Batson, James W Choi, Debbie L Cohen, George Dangas, Shukri David, Justin Davies, Chandan M Devireddy, David Kandzari, David P Lee, Philipp C Lurz, Vasilios Papademetriou, Manesh Patel, Kiritkumar Patel, Roland E Schmieder, Andrew SP Sharp, Jasvindar Singh, Antony Walton, Thomas Weber, Joachim Weil, Thomas Zeller, Khaled Ziada, Kengo Tanabe, Robert Wilkins, Robert Wilensky, Johanna Contreras, Susan Steigerwalt, Neil Chapman, Janice P Lea, Denise Reedus, Satoshi Hoshide, Adrian Ma, Karl Fengler, Ping Li, Laura Svetkey, Anjani Rao, Axel Schmid, Anthony F Watkinson, Angela Brown, Ingrid Hopper, Markus Suppan, Tolga Agdirlioglu, Elias Noory, Craig Chasen
发表日期
2018/6/9
期刊
The Lancet
卷号
391
期号
10137
页码范围
2346-2355
出版商
Elsevier
简介
Background
Previous catheter-based renal denervation studies have reported variable efficacy results. We aimed to evaluate safety and blood pressure response after renal denervation or sham control in patients with uncontrolled hypertension on antihypertensive medications with drug adherence testing.
Methods
In this international, randomised, single-blind, sham-control, proof-of-concept trial, patients with uncontrolled hypertension (aged 20–80 years) were enrolled at 25 centres in the USA, Germany, Japan, UK, Australia, Austria, and Greece. Eligible patients had an office systolic blood pressure of between 150 mm Hg and 180 mm Hg and a diastolic blood pressure of 90 mm Hg or higher; a 24 h ambulatory systolic blood pressure of between 140 mm Hg and 170 mm Hg at second screening; and were on one to three antihypertensive drugs with stable doses for at least 6 weeks. Patients underwent renal …
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DE Kandzari, M Böhm, F Mahfoud, RR Townsend… - The Lancet, 2018