作者
Pierre Seners, Catherine Oppenheim, Guillaume Turc, Jean‐François Albucher, Adrien Guenego, Nicolas Raposo, Soren Christensen, Lionel Calvière, Alain Viguier, Jean Darcourt, Anne‐Christine Januel, Michael Mlynash, Agnes Sommet, Claire Thalamas, Igor Sibon, Vanessa Rousseau, Thomas Tourdias, Patrice Menegon, Fabrice Bonneville, Mikael Mazighi, Sylvain Charron, Laurence Legrand, Christophe Cognard, Gregory W Albers, Jean‐Claude Baron, Jean‐Marc Olivot, FRAME investigators, François Chollet, Louis Fontaine, Marianne Barbieux, Caterina Michelozzi, Philippe Tall, François Caparros, Brigitte Pouzet, Fabienne Calvas, Monique Galitzki, Amel Drif, Pauline Renou, François Rouanet, Jerome Berge, Gauthier Marnat, Patrice Menegon, Ludovic Lucas, Cyrielle Coignon, Sharmila Sagnier, Sabrina Debruxelle, Sylvain Ledure
发表日期
2021/9
期刊
Annals of Neurology
卷号
90
期号
3
页码范围
417-427
出版商
John Wiley & Sons, Inc.
简介
Objective
Mechanical thrombectomy (MT) is not recommended for acute stroke with large vessel occlusion (LVO) and a large volume of irreversibly injured tissue (“core”). Perfusion imaging may identify a subset of patients with large core who benefit from MT.
Methods
We compared two cohorts of LVO‐related patients with large core (>50 ml on diffusion‐weighted‐imaging or CT‐perfusion using RAPID), available perfusion imaging, and treated within 6 hours from onset by either MT + Best Medical Management (BMM) in one prospective study, or BMM alone in the pre‐MT era from a prospective registry. Primary outcome was 90‐day modified Rankin Scale ≤2. We searched for an interaction between treatment group and amount of penumbra as estimated by the mismatch ratio (MMRatio = critical hypoperfusion/core volume).
Results
Overall, 107 patients were included (56 MT + BMM and 51 BMM …
学术搜索中的文章
P Seners, C Oppenheim, G Turc, JF Albucher… - Annals of Neurology, 2021