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The specificity of cytotoxic T lymphocytes (T_c) cells is conferred by an antigen-specific receptor, Ti, which in humans is physically associated with an invariant cell-surface glycoprotein, T3 (refs. 1–3). Monoclonal antibodies specific for either T3 and Ti are able to elicit a variety of T-cell responses such as lymphokine production, mitogenesis and cytotoxicity^1–11. For example, human T_c cells lyse anti-T3-expressing hybridoma cells, but not cells of other specificity, presumably because anti-T3 on the hybridoma cells binds to T3 on the T_c cells and triggers lysis¹². Here, we have adapted approaches used in a different cytotoxic effector system, antibody-dependent cellular cytotoxicity (ADCC), to alter the specificity of T_c cell. Studies of ADCC¹³ showed that heteroaggregates containing anti-Fc receptor (FcγR) antibody cross-linked to a second antibody bind to FcγR on ADCC effectors and cause them to kill target cells …