作者
Xunian Zhou, Huichang Bi, Jing Jin, Lu Niu, Dake Cai, Rongrong Deng, Yuhua Li, Yongtao Wang, Min Huang
发表日期
2013/11
期刊
Planta Med
卷号
79
期号
17
页码范围
1641-7
简介
Praeruptorin A and praeruptorin C, racemic to each other, are main bioactive constituents of the species Peucedanum praeruptorum, traditionally used as a Chinese herbal medicine (also known as Bai-Hua Qian Hu). In the present study, the ability of praeruptorins A and C to activate the constitutive androstane receptor and induce human multidrug resistance-associated protein 2 expressions in HepG2 cells was investigated. The changes in mRNA level, protein expression, and transport activity of multidrug resistance-associated protein 2 were determined by quantitative real-time PCR, Western blot, and the CDF uptake assay, respectively. The effects of constitutive androstane receptor knockdown on multidrug resistance-associated protein 2 mRNA and protein expression were …
学术搜索中的文章
X Zhou, H Bi, J Jin, L Niu, D Cai, R Deng, Y Li, Y Wang… - Planta medica, 2013