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Prenatal stress and associated in utero exposure to elevated levels of stress hormones can adversely affect the development of the central nervous system, thereby increasing the risk of mental illnesses in later life. Here, we examined the impact of prenatal exposure to chronic mild stress (CMS) on locomotion, anxiety-related behaviour, cognition and hippocampal serotonergic neurotransmission in juvenile and adult B6D2F2 mice, and whether antidepressant treatment in adulthood could reverse the observed behavioural disturbances. Pregnant B6D2F1 female mice were either subjected to CMS or left undisturbed until parturition. Three-week and 7-week-old male and female offspring were assessed in the open-field, novel object recognition and contextual fear conditioning tests. Hippocampal levels of serotonin and its major metabolite were then quantified using high-performance liquid chromatography. Some …