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Alzheimer's disease (AD) is an incurable age-related neurodegenerative condition, characterised by progressive decline in cognitive and physical functions, and extensive brain damage. Identifying cognitive deficits that accompany early AD is critical, as the accompanying synaptic changes can be effectively targeted by current treatments – at present AD is typically not diagnosed until brain pathology is established, and treatment relatively ineffective. We therefore examined early cognitive changes in 4-month-old mice over-expressing 2 genes responsible for AD (APPswe/PS1d9 mouse line). Experiment 1 tested 4-month-old female APPswe/PS1dE9 mice and their wild-type littermates on 4 validated tasks involving 8 cognitive and non cognitive measures. We observed a selective deficit in extinction of contextual fear in APPswe/PS1dE9 mice. To extend the generality of this finding, Experiment 2 examined …