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The ongoing COVID-19 pandemic has to date infected more than 1 million people and led to tens of thousands of deaths across the globe. Thus, many governments have imposed regional or national mass shelters-in-place in an effort to slow its rapid spread. In this global health emergency, special attention should be paid to the potential impact of the measures taken to combat the pandemic on patients with bipolar disorders (BDs). Shelter-in-place and quarantine are key public health tools, yet they have high psychological and economic costs. They require sacrificing daily routines and public/personal social encounters that enhance health and quality of life and provide emotional support. Even in the general population, the length of social isolation and the constrained physical space in which isolation takes place can be associated with a wide range of adverse psychological effects, including depression …