作者
Shulamite A Green, Jeffrey D Rudie, Natalie L Colich, Jeffrey J Wood, David Shirinyan, Leanna Hernandez, Nim Tottenham, Mirella Dapretto, Susan Y Bookheimer
发表日期
2013/11/1
期刊
Journal of the American Academy of Child & Adolescent Psychiatry
卷号
52
期号
11
页码范围
1158-1172
出版商
Elsevier
简介
Objectives
Sensory over-responsivity (SOR), defined as a negative response to or avoidance of sensory stimuli, is both highly prevalent and extremely impairing in youth with autism spectrum disorders (ASD), yet little is known about the neurological bases of SOR. This study aimed to examine the functional neural correlates of SOR by comparing brain responses to sensory stimuli in youth with and without ASD.
Method
A total of 25 high-functioning youth with ASD and 25 age- and IQ-equivalent typically developing (TD) youth were presented with mildly aversive auditory and visual stimuli during a functional magnetic resonance imaging (fMRI) scan. Parents provided ratings of children's SOR and anxiety symptom severity.
Results
Compared to TD participants, ASD participants displayed greater activation in primary sensory cortical areas as well as amygdala, hippocampus, and orbital-frontal cortex. In both groups, the …
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SA Green, JD Rudie, NL Colich, JJ Wood, D Shirinyan… - Journal of the American Academy of Child & …, 2013