作者
Sajesh K Veettil, Peerawat Jinatongthai, Surakit Nathisuwan, Nattawat Teerawattanapong, Siew Mooi Ching, Kean Ghee Lim, Surasak Saokaew, Pochamana Phisalprapa, Christopher M Reid, Nathorn Chaiyakunapruk
发表日期
2018/10/10
来源
Clinical epidemiology
页码范围
1433-1445
出版商
Taylor & Francis
简介
Background
Various interventions have been tested as primary prevention of colorectal cancers (CRC), but comprehensive evidence comparing them is absent. We examined the effects of various chemopreventive agents (CPAs) on CRC incidence and mortality.
Methods
We did a network meta-analysis based on a systematic review of randomized controlled trials (RCTs) that compared at least one CPA (aspirin, antioxidants, folic acid, vitamin B6, vitamin B12, calcium, vitamin D, alone or in combination) to placebo or other CPA in persons without history of CRC. Several databases were searched from inception up to March 2017. Primary outcomes were early and long-term CRC incidence and mortality.
Results
Twenty-one RCTs comprising 281,063 participants, 9 RCTS comprising 160,101 participants, and 7 RCTs comprising 24,001 participants were included in the network meta-analysis for early risk of CRC …
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SK Veettil, P Jinatongthai, S Nathisuwan… - Clinical epidemiology, 2018