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To review the pharmacology, pharmacokinetics, pharmacodynamics, efficacy data, and adverse effects of indiplon in the treatment of transient and chronic insomnia in adult and geriatric patients.

A literature search was conducted using MEDLINE (1966–May 2006), International Pharmaceutical Abstracts (1970–May 2008), and Cochrane database (2007) (or the key words indiplon or NBI-34060. References cited in the articles were reviewed for additional Information. Abstract data were included only in the absence of significant published data.

English-language literature reporting animal and human clinical studies was reviewed to evaluate data on the pharmacology, pharmacokinetics, pharmacodynamics, efficacy, and adverse effects of indiplon. Clinical trials selected for inclusion were limited to those with human subjects, with the accepted Inclusion of …